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It typically comes down to two factors: what she's wearing, and how she's wearing it<br><br>This can become an important factor if you are playing a game and find that your shoes are damp and heavy from the perspiration. You'll be hard-pressed to find someone who has not wanted or owned a pair of these basketball shoes at some point in their lifetime. For people who suffer from a condition called epidermolysis bullosa, however, blisters can be life-threatening. Take them off if you've got little kids crawling around on the floors, who may then put their fingers in their mouths. Even the friction created by walking, crawling and playing can lead to blisters. People with EB have fragile skin; even mild heat and friction can create injuries and cause blisters. Human skin also has a defense system that goes to work when its integrity gets compromised by injuries from friction or heat. 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